Affects especially the rheumatic diathesis, going through all the changes, from functional pain to altered secretions and deposits of solid, earthy matter in the tissues. The Ledum rheumatism begins in feet, and travels upward. It affects also the skin, producing an eruption like Poison-oak, and is antidotal thereto, as well as to stings of insects. There is a general lack of animal heat, and yet heat of bed is intolerable. For punctured wounds, produced by sharp-pointed instruments or bites particularly if the wounded parts are cold, this is the remedy. Tetanus with twitching of muscles near wound.